Endocrine Abstracts

Familial isolated pituitary adenoma (FIPA) occurs if two or more members of a family develop pituitary adenoma with no features of multiple endocrine neoplasia type 1 or Carney complex. FIPA is an autosomal dominant disease with incomplete penetrance. FIPA families can be divided into two distinct groups based on genetic and phenotypic features. In 20% of FIPA families mutations have been identified in the aryl hydrocarbon receptor interacting protein (AIP) gene. The AIP-posit...

Introduction: Human tear is rich in cytokines, i.e. in healthy individuals it exhibits a higher ratio of cytokines to total proteins than that in the serum of the same individual. EOP related to Graves–Basedow disease is thought to develop due to elevation of serum cytokine levels and to an altered cytokine response of the intra- and periorbital tissues. In our present study we focused on the measurement of IL6, IL8 and TNF-α, the relative amount of a lipocalin-type ...

During the evaluation of hypercortisolism, distinction between Cushing’s disease (CD) and ectopic ACTH syndrome (EAS) may be problematic. Detailed medical history, diagnostic procedures and pitfalls associated with EAS of four cases are presented. All the four patients had ectopic Cushing’s syndrome due to typical bronchial carcinoids. Their mean age was 39 years, and the mean time from the presentation of Cushing’s symptomes until diagnosis and definitive cure ...